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We develop next generation technologies to interrogate and perturb mammalian epigenome, transcriptome and epitranscriptome in a programmable and predictable manner using cutting-edge molecular biology and synthetic biology approach. We use nuclease dead CRISPR-Cas (Cas9, Cas12, Cas13) as a starting material / building block and playing around different self / orthogonal proteins and RNAs to build the molecular tools for interrogating, spatio-temporally regulating novel functions of cells and potential biomedical applications. Beyond molecular technology development, we want to understand how expression stoichiometry of different gene regulatory proteins modulates cell fate reprogramming.
We are particularly interested in
Developing molecular tools and technologies for perturbing human epigenome, transcriptome and epitranscriptome
Fine tuning the expression of endogenous lineage defining transcription factors (LDTFs) for efficient lineage reprogramming
Developing epigenome editing based gene therapy as genetic medicines for complex and rare diseases
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