Publications

2026

Ganglioside GM2 induces epithelial–mesenchymal transition (EMT) in cancer cells in a MEK/ERK/Egr1-dependent transcriptional program

Khamrui, E., Banerjee, S., Ray, S., Ray, A., Mahata, B., Das, T., Ghosh, Z. & Biswas, K. 

Journal of Biological Chemistry, Volume 302, Issue 4, April 2026

2025

Biomolecular condensation of human IDRs initiates endogenous transcription via intrachromosomal looping or high-density promoter localization

Li, J., Liu, S., Kim, S., Goell, J., Drum, Z.A., Flores, J.P., Ma, A.J., Mahata, B., Escobar, M., Raterink, A., Ahn, H.J., Terán, E.R., Guerra-Resendez, R.S., Zhou, Y., Yu, B., Diehl, M., Wang, G.G., Gustavsson, A.K., Phanstiel, D.H. & Hilton, I.B. 

Nucleic Acids Research, Volume 53, Issue 4, February 2025

2024

Persistent tailoring of MSC activation through genetic priming

Beauregard, M.A., Bedford, G., Brenner, D., Solis, L.D.S., Nishiguchi, T., Abhimanyu, Longlax, S.C., Mahata, B., Veiseh, O., Wenzel, P.L., DiNardo, A.R., Hilton, I.B. & Diehl, M.R. 

Molecular Therapy Methods & Clinical Development, Volume 32, Issue 3, September 2024

2023

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

Mahata, B., Cabrera, A., Brenner, D.A., Guerra-Resendez, R.S., Li, J., Goell, J., Wang, K., Guo, Y., Escobar, M., Parthasarathy, A.K., Szadowski, H., Bedford, G., Reed, D. & Hilton, I.B. 

Nature Methods, 20, 1716–1728, October 2023

2022

Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer–promoter interactions

Wang, K., Escobar, M., Li, J., Mahata, B., Goell, J., Shaw, S., Cluck, M. & Hilton, I.B.

Nucleic Acids Research, Volume 50, Issue 14, August 2022

Eriodictyol mediated selective targeting of TNFR1/FADD/TRADD axis in cancer cells induces apoptosis and inhibits tumor progression and metastasis

Debnath, S., Sarkar, A., Das Mukherjee, D., Ray, S., Mahata, B., Mahata, T., Parida, P.K., Das, T., Mukhopadhyay, R., Ghosh, Z. & Biswas, K. 

Translational Oncology, Volume 21, July 2022

2021

Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

Li, J., Mahata, B., Escobar, M., Goell, J., Wang, K., Khemka, P. & Hilton, I.B.

Nature Communications, 12, 896, February 2021

2019

Elevated H3 acetylation and loss of Sp1–HDAC1 complex derepress the GM2 synthase gene in renal cell carcinoma

Banerjee, A., Mahata, B., Dhir, A., Mandal, T.K. & Biswas, K.

Journal of Biological Chemistry, Volume 294, Issue 3, January 2019

2018

Inhibition of cancer progression by a novel trans-stilbene derivative of resveratrol by interfering with microtubule dynamics, driving G2/M arrest and p53-dependent apoptosis

Parida, P.K., Mahata, B., Santra, A., Chakraborty, S., Ghosh, Z., Raha, S., Mishra, A.K., Biswas, K. & Jana, K.

Cell Death & Disease, 9, 448, April 2018

2016

Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating downstream signaling pathway

Kundu, M., Mahata, B., Banerjee, A., Chakraborty, S., Debnath, S., Ray, S.S., Ghosh, Z. & Biswas, K.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1863, Issue 7, Part A, July 2016

2015

GBM-derived gangliosides induce T cell apoptosis through activation of the caspase cascade involving both the extrinsic and intrinsic pathway

Mahata, B., Biswas, S., Rayman, P., Chahlavi, A., Ko, J., Bhattacharjee, A., Li, Y.T., Li, Y., Das, T., Sa, G., Raychaudhuri, B., Vogelbaum, M.A., Tannenbaum, C., Finke, J.H. & Biswas, K.

PLoS One, 10(7), July 2015

TALEN-mediated targeted editing of GM2/GD2-synthase gene modulates anchorage-independent growth by reducing anoikis resistance in mouse tumor cells

Mahata, B., Banerjee, A., Kundu, M., Bandyopadhyay, U. & Biswas, K. 

Scientific Reports, 5, 9048, March 2015